Background on Chromosome Abnormalities
There are 23 pairs of chromosomes (for a total of 46 chromosomes) in most cells of the human body. Chromosomes contain the genetic information that tells the body how to grow and develop. Half of the chromosomes are inherited from the egg and half are inherited from the sperm. The presence of extra or missing chromosomes is called aneuploidy. Embryos that have extra or missing chromosomes often develop improperly, are less likely to implant and are more likely to miscarry. Most of these pregnancies miscarry by the end of the first trimester, but some chromosomally normal pregnancies can continue and cause disorders in live-born babies.
染色体异常背景
在人体的大多数细胞中, 有23对染色体 (共46条染色体)。染色体包含告诉身体如何生长和发育的基因信息。一半的染色体是从卵子中继承来的, 一半是从精子中遗传的。多余或缺失染色体的存在称为体检。有多余或缺失染色体的胚胎往往发育不当, 不易植入, 更容易流产。这些怀孕中的大多数在孕晚期流产, 但一些染色体正常怀孕可能会继续存在, 并导致出生婴儿的疾病。
Down syndrome, caused by an extra copy of chromosome 21, is the most commonly seen aneuploidy in live-born babies, although there are other aneuploidies that can result in more serious syndromes and can also be carried to term. Every couple will produce some embryos that have chromosome abnormalities. The rate increases as the woman gets older. With PGS testing, embryos are screened for extra or missing chromosomes, and those found to be chromosomally normal are preferentially transferred to the uterus for implantation.
Kunhe and Dr. Lee expectation is that, by screening for extra or missing chromosomes prior to embryo transfer:
坤和李博士期望的是, 在胚胎移植之前, 通过筛查多余或缺失的染色体:
The chance of implantation and pregnancy can be increased.
The chance for miscarriage can be decreased.
The chance for a live birth with normal chromosomes can be increased.
植入和怀孕的机会可以增加。
流产的几率可以减少。
正常染色体的活产几率可以增加。
PGS Services at kunhe
24 CHROMOSOME PGS FOR IVF
Our aneuploidy screening platforms are comprehensive tests that examines all 24 chromosomes including autosomes 1-22, and the sex chromosomes (X, Y).
CGH
NGS
DETECTING UNBALANCED TRANSLOCATION FOR IVF
An unbalanced translocation occurs when an embryo inherits a chromosome with extra or missing genetic material from a parent with a balanced translocation. Unbalanced translocations often result in miscarriage, or can lead to the birth of a child with intellectual disability and/or birth defects. Our microarray platform is optimized to detect chromosomal deletions and duplications larger than 1.8-3Mb in size, and to our knowledge, is the most sensitive test clinically available today.
